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Literature summary for 3.2.2.31 extracted from

  • Chepanoske, C.L.; Lukianova, O.A.; Lombard, M.; Golinelli-Cohen, M.P.; David, S.S.
    A residue in MutY important for catalysis identified by photocross-linking and mass spectrometry (2004), Biochemistry, 43, 651-662 .
    View publication on PubMed
Search for more literature for 3.2.2.31

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mispair + H2O Escherichia coli
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 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing a 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mispair + H2O
-
 Escherichia coli ?
-
 ?
DNA containing a cytosine:adenine mispair + H2O
-
 Escherichia coli ?
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 ?
DNA containing a guanine:adenine mispair + H2O
-
 Escherichia coli ?
-
 ?
additional information the enzyme recognizes but shows no enzymatic activity with the 2'-deoxyadenosine analogs 2'-deoxytubercidin and 2'-deoxyformycin A Escherichia coli ?
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 ?

Synonyms

Synonyms Comment Organism
mutY
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 Escherichia coli

General Information

General Information Comment Organism
physiological function the enzyme plays an important role in the prevention of DNA mutations caused by the oxidatively damaged lesion 7,8-dihydro-8-oxo-2'-deoxyguanosine by removal of misincorporated adenine residues in 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatched base pairs using N-glycosylase activity Escherichia coli